I had no prostate issues with primo. It's possible though some guys do.My only concern is prostate problems.. Please make sure you don't have problems with it before begin the cycle.
Rest, i did many high dose primo cycles. And I believe using it 300-400 mg is just a waste..
I did 800 mg / week many times.. i believe you start to see real results of primo on 500mg+/week and it become really fun at 800 mg. If you want to use it, i'd start somewhere 500-600/week..
I never run it at 1g/week. ..