Not really. I seem to do well with higher E2.
My libido and erection is always good, always horny. No acne, except an occasional pimple on the back. No problem sleeping. Energy is good. This level is nothing. I have tested as high has 79pg with 950ng testosterone in the past. I think from doing subq/shallow IM.
I switched to IM with proper 1" needle and this may have lowered estradiol or my body just adjusted. My testosterone is higher and estradiol is lower than before.
Even at 79pg, never had any issues. The only time I had a problem was 2 years ago, when I was using a compounding cream which for the first 6 months worked fine, then it stopped working, despite increasing the dose.
My testosterone plummeted to 150ng and I started getting acne all over from higher estradiol to test level I believe. I never had as much acne activity on my back as then, not even now at 1360ng
I'd prefer to do TRT with no AI, tho my dose and levels are more sports TRT
I plan to do a 16 week blast on 500mg testosterone only and add 1mg a week anastrozole and see how I do.
My suspicion is with anastrozole 1mg, my estradiol should be around 80 tops or maybe less while on 500mg, so I should be technically fine